an Endocrine Society Thematic Issue
Read our special collection of journal articles, published in 2021–2023, describing research on Endocrine-disrupting Chemicals (EDCs)! Curation of the collection was guided by Altmetric Attention Scores and Featured Article designations.
In Endocrinology, Casiano and colleagues discuss two less-studied EDCs, per- and polyfluoroalkyl substances and the parabens, in terms of the disparities in exposure between populations and their association with breast carcinogenesis. Tong and coauthors report that a mouse model of mammary cancer metastasis exposed to methylparaben and propylparaben at levels lower than the US Food and Drug Administration’s “human acceptable daily intake” had increased tumor volumes and rates of pulmonary metastases. Hilz and Gore review recent evidence for sex-specific changes to the brain’s monoaminergic systems after developmental EDC exposure and relate these to sex differences in cognition.
In Journal of the Endocrine Society, Ogunsina et al. report an almost 40 percent serum thyroid peroxidase antibody positivity rate among firefighters, who may be exposed to EDCs in their work. Ding and associates report a significant association between urinary phthalate metabolites and both anti-Müllerian hormone and testosterone in data from the Study of Women’s Health Across the Nation (SWAN). Vazquez, Daza-Dueñas, and Tena-Sempere review epigenetic effects influencing reproduction, noting that EDCs, through their effects on androgen and estrogen signaling, likely can cause suppressed gametogenesis, among a host of other effects.
In JCEM, Peng and colleagues report that in data from SWAN, some phthalate metabolites were associated with a higher incidence of diabetes over a 6-year period, although the associations were inconsistent across racial/ethnic groups. Timmermann et al. report that increased serum concentrations of perfluoroalkyl substances were associated with an increased risk of terminating breastfeeding. Carwile and coauthors describe how serum levels of polyfluoroalkyl substances and phthalates may be associated with reduced bone mineral density in adolescent males.
In Endocrine Reviews, Brito and associates discuss the possible influence of EDCs in acquired mechanisms implicated in central precocious puberty. They note growing but inconclusive evidence linking critical developmental periods of EDC exposure to pubertal developmental disorders via a neuroendocrine route. Yang and coauthors provide a comprehensive review of uterine fibroids, highlighting several studies that have linked EDC exposure to their development; phthalates seem to be tightly linked to fibroid prevalence. Clark and associates review what is known about ovarian Hippo signaling, a key mediator of ovarian homeostasis in response to environmental toxicants such perfluorooctanoic acid and tri-ortho-cresyl phosphate.
Published: February 2023
It can be difficult to keep up to date in the rapidly evolving and expanding world of endocrine science. We curate topical collections of research from across our journals, Endocrine Reviews, Endocrinology, Journal of the Endocrine Society, The Journal of Clinical Endocrinology & Metabolism, and JCEM Case Reports so that you can easily find and read recent, influential articles on the topics that interest you.
Selection in each Thematic Issue is guided by online metrics, including Altmetric Attention Scores, Featured Article designations, and identification of leading authors and key topics. Each month, we publish a new Thematic Issue online and work to highlight and promote endocrine science in the press, through email, on social media and across other distribution channels.
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