an Endocrine Society Thematic Issue
Read our special collection of journal articles with authors who are fellows of the Society’s FLARE program! FLARE (Future Leaders Advancing Research in Endocrinology) is the Endocrine Society’s program for basic and clinical research trainees and junior faculty from underrepresented minority communities who have demonstrated achievement in endocrine research. Curation of the collection was guided by the number of article downloads and publication in 2020 or later.
In JCEM, Joo and coauthors demonstrated the value of integrated polygenic risk scores in a phenome-wide association study to improve the detection of cases of polycystic ovary syndrome (PCOS) across European-, African-, and multi-ancestry participants. Kazemi et al. reported that women with PCOS exhibit early signs of osteosarcopenia when compared with controls. Pinney and colleagues reported that human amniocytes exposed to gestational diabetes in utero showed enrichment of inflammation- and interferon-related pathways as well as novel differentially methylated regions in gene expression analysis. Vasandani and coauthors identified the best anthropometric measurement for diagnosing familial partial lipodystrophy, Dunnigan variety, in females.
Boutin and Burnett-Bowie described in JCEM Case Reports the successful use of denosumab and teriparatide to treat a spiral humeral fracture complicated by nonunion in a woman with obesity and type 2 diabetes. Yu and associates wrote about a novel, dominant, heterozygous, likely pathogenic variant in the NR5A1 gene associated with a severely undervirilized male phenotype that was initially thought to be caused by congenital adrenal hyperplasia. Gabbay et al. reported on a rare case of a woman who was found to have both a pituitary adenoma causing acromegaly and a cortisol-producing adrenal adenoma causing Cushing syndrome within 1 year. Taiwo and coauthors provided descriptions of two cases of pituitary Crooke cell adenoma, a rare, aggressive form of pituitary adenoma.
In Endocrinology, Bethea and coauthors reviewed preproglucagon products and their involvement in regulating insulin secretion to “update the current understanding of the role of glucagon and α-cell–derived GLP-1.”
In Endocrine Reviews, Jha and Simonds discussed the molecular and clinical spectrum of primary hyperparathyroidism (PHPT), noting that genetic testing for heritable forms should be offered to patients with multiglandular disease, recurrent PHPT, young onset PHPT (age 40 years or less), and those with a family history of parathyroid tumors.
The FLARE fellows who contributed to these articles respectively are Ky’era Actkins, Maryam Kazemi, Cetewayo Rashid, Chandna Vasandani, Regine Boutin, Lina Huerta-Saenz, Natalia Chamorro-Pareja, Adeyinka Taiwo, Maigen Bethea, and Smita Jha.
Published: September 2024
It can be difficult to keep up to date in the rapidly evolving and expanding world of endocrine science. We curate topical collections of research from across our journals, Endocrine Reviews, Endocrinology, Journal of the Endocrine Society, The Journal of Clinical Endocrinology & Metabolism, and JCEM Case Reports so that you can easily find and read recent, influential articles on the topics that interest you.
Selection in each Thematic Issue is guided by online metrics, including Altmetric Attention Scores, Featured Article designations, and identification of leading authors and key topics. Each month, we publish a new Thematic Issue online and work to highlight and promote endocrine science in the press, through email, on social media and across other distribution channels.
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